Colombo G L
Ann Ig. 2002 Sep-Oct;14(5):373-88.
Streptococcus pneumoniae (S pneumoniae, or pneumococcus) is a leading cause of illness in children, and causes illness and death among the elderly and persons with certain underlying conditions. A Cost-of-Illness (COI) estimate for each pneumococcal disease (meningitis, bacteremia, pneumonia, and otitis media) was determined using decision tree analysis that considered both direct and indirect costs. Information on the burden of pneumococcal disease in Italy, in terms of data on the incidence and seroprevalence of disease was collected from published and unpublished records, supplemented, and verified by Italian pediatric and infectious disease experts. The annual cost to society of caring for children with pneumococcal disease is estimated to be around 59,604,477 euro including both direct costs and indirect costs (productivity changes). Direct costs accounted for 39.9% of the total costs. The value of resources used to treat otitis media was 60.6% of the total direct costs; 31.9% was the value of resources for treating pneumonia; 6.5% for treating bacteremia; 1.0% for treating meningitis. A sensitivity analysis confirmed the robustness of the results.
肺炎链球菌（肺炎链球菌，或肺炎球菌）是儿童患病的主要原因，并且在老年人和患有某些基础疾病的人群中导致疾病和死亡。使用考虑了直接和间接成本的决策树分析确定了每种肺炎球菌疾病（脑膜炎、菌血症、肺炎和中耳炎）的疾病成本（COI）估计值。关于意大利肺炎球菌疾病负担的信息，根据疾病发病率和血清阳性率的数据，从已发表和未发表的记录中收集，并由意大利儿科和传染病专家进行补充和核实。照顾患有肺炎球菌疾病儿童的社会年度成本估计约为59,604,477欧元，包括直接成本和间接成本（生产力变化）。直接成本占总成本的39.9%。用于治疗中耳炎的资源价值占总直接成本的60.6%；用于治疗肺炎的资源价值占31.9%；用于治疗菌血症的资源价值占6.5%；用于治疗脑膜炎的资源价值占1.0%。敏感性分析证实了结果的稳健性。
