Disalvo J, Schmidt C, Leavitt W W, Reuss B
Proc Soc Exp Biol Med. 1976 Jan;151(1):207-11. doi: 10.3181/00379727-151-39175.
Angiotensin I (A-I) and angiotensin II (A-II) produced dose-dependent increases in isometric tension in isolated strips of uterine smooth muscle prepared from ovariectomized golden hamsters treated with estrogen. Responses to A-II were consistent with receptor--occupancy theory of agonist--receptor interactions. Inhibition of angiotensin-converting enzyme virtually abolished responses to A-I but not those to A-II. Blockade of A-II receptors inhibited responses to both A-I and A-II. Cholinergic or alpha-adrenergic blockade did not alter uterine responses to either A-I or A-II. These findings suggest that contractile responses elicited in the isolated uterus of the hamster are due to its local conversion to A-II and subsequent interactions with specific A-II receptors. Such conversion occurs at least to the extent of 14 to 27 %.
血管紧张素I（A-I）和血管紧张素II（A-II）使经雌激素处理的去卵巢金黄仓鼠制备的离体子宫平滑肌条的等长张力产生剂量依赖性增加。对A-II的反应符合激动剂-受体相互作用的受体占据理论。血管紧张素转换酶的抑制几乎消除了对A-I的反应，但对A-II的反应没有消除。A-II受体的阻断抑制了对A-I和A-II的反应。胆碱能或α-肾上腺素能阻断不会改变子宫对A-I或A-II的反应。这些发现表明，仓鼠离体子宫中引发的收缩反应是由于其局部转化为A-II以及随后与特定A-II受体的相互作用。这种转化至少发生在14%至27%的程度。
