Jørgensen Peter, Schäfer Carsten, Guerra Peter G, Talajic Mario, Nattel Stanley, Glass Leon
Center for Nonlinear Dynamics, Department of Physiology, McGill University, 3655 Drummond St., Montréal, Québec, Canada H3G1Y6.
Bull Math Biol. 2002 Nov;64(6):1083-99. doi: 10.1006/bulm.2002.0313.
This work develops a mathematical model for the atrioventricular (AV) node in the human heart, based on recordings of electrical activity in the atria (the upper chambers of the heart) and the ventricles (the lower chambers of the heart). Intracardiac recordings of the atrial and ventricular activities were recorded from one patient with atrial flutter and one with atrial fibrillation. During these arrhythmias, not all beats in the atria are conducted to the ventricles. Some are blocked (concealed). However, the blocked beats can affect the properties of the AV node. The activation times of the atrial events were regarded as inputs to a mathematical model of conduction in the AV node, including a representation of AV nodal concealment. The model output was compared to the recorded ventricular response to search for and identify the best possible parameter combinations of the model. Good agreement between the distribution of interbeat intervals in the model and data for durations of 5 min was achieved. A model of AV nodal behavior during atrial flutter and atrial fibrillation could potentially help to understand the relative roles of atrial input activity and intrinsic AV nodal properties in determining the ventricular response.
这项研究基于对心房（心脏上部腔室）和心室（心脏下部腔室）电活动的记录，开发了一种用于人类心脏房室（AV）结的数学模型。从一名患有心房扑动和一名患有心房颤动的患者身上记录了心房和心室活动的心内记录。在这些心律失常期间，并非心房中的所有搏动都传导至心室。有些被阻滞（隐匿）。然而，被阻滞的搏动会影响房室结的特性。心房事件的激活时间被视为房室结传导数学模型的输入，包括房室结隐匿的表示。将模型输出与记录的心室反应进行比较，以寻找并确定模型的最佳参数组合。模型中搏动间期的分布与5分钟时长的数据之间取得了良好的一致性。心房扑动和心房颤动期间的房室结行为模型可能有助于理解心房输入活动和房室结固有特性在决定心室反应中的相对作用。
