肾脏激肽原酶的分布

Distribution of kidney kininogenases.

作者信息

Scicli A G, Carretero O A, Oza N B, Schork M A

出版信息

Proc Soc Exp Biol Med. 1976 Jan;151(1):57-60. doi: 10.3181/00379727-151-39142.

Abstract

The distribution of kininogenase activity in the dog kidney was studied. It was found that kininogenase decreased from the outer to the inner cortex and that the medulla and papilla have very little kininogenase activity. Kininogenase activity was also measured in isolated glomeruli devoid of juxtaglomerular apparatus and in the total cortex of rat kidney. In the isolated glomeruli, the kininogenase activity per milligram of protein was only 15% of that found in the total cortex. It was concluded that the main localization of these enzymes is not in the glomeruli, but somewhere else in the cortical segment of the nephron.

摘要

对犬肾中激肽原酶活性的分布进行了研究。发现激肽原酶从肾皮质外层到内层逐渐减少，而髓质和乳头的激肽原酶活性非常低。还测定了不含球旁器的分离肾小球以及大鼠肾全皮质中的激肽原酶活性。在分离的肾小球中，每毫克蛋白质的激肽原酶活性仅为全皮质中该活性的15%。得出的结论是，这些酶的主要定位不在肾小球，而在肾单位皮质段的其他部位。