Koletsky S, Puterman D I
Proc Soc Exp Biol Med. 1976 Feb;151(2):368-71. doi: 10.3181/00379727-151-39212.
A new strain of genetically obese rat recently obtained in our laboratory exhibits endogenous hyperlipidemia (marked hypertriglyceridemia and moderate hypercholesterolemia) and spontaneous hypertension. The animals die prematurely from kidney failure or from the complications of atherosclerosis. A low calorie diet proved to be highly beneficial to these rats. Body weight declined, obesity diminished, the hypertriglyceridemia was almost eliminated, and the hypercholesterolemia was reduced. However, the hypertensive state was not alleviated. Since the life span of the rats was greatly prolonged by a low calorie diet, the latter undoubtedly served to prevent or arrest the development of renal and vascular disease in these obese animals.
我们实验室最近获得的一种新型遗传性肥胖大鼠表现出内源性高脂血症（显著的高甘油三酯血症和中度高胆固醇血症）以及自发性高血压。这些动物过早死于肾衰竭或动脉粥样硬化并发症。事实证明，低热量饮食对这些大鼠非常有益。体重下降，肥胖减轻，高甘油三酯血症几乎消除，高胆固醇血症减轻。然而，高血压状态并未得到缓解。由于低热量饮食大大延长了大鼠的寿命，后者无疑有助于预防或阻止这些肥胖动物肾脏和血管疾病的发展。
