Song Shuijiang, Zheng Xiaohong, Wen Shuqun, Huang Jianzheng, Ding Deyun
Department of Neurology, The Second Affiliated Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310009, China.
Zhonghua Yi Xue Za Zhi. 2002 Nov 10;82(21):1447-9.
To explore the changes of the levels of soluble intercellular adhesion molecule-1 (sICAM-1) and basic fibroblast growth factor (bFGF) in serum of patients with acute cerebral infarction, and the effects of sICAM-1 and bFGF on cerebral infarction.
ELISA was used to detect the serum sICAM-1 and bFGF of 55 patients with acute cerebral infarction (within 2 days) as well as 32 patients diagnosed as with other neurologic diseases (20 patients with sciatica and 12 with trigeminal neuralgia) and 30 healthy persons as controls.
(1) Both serum sICAM-1 and bFGF in the infarction group were significantly higher [(766.2 +/- 178.8) micro g/L and (17.4 +/- 8.2) micro g/L respectively] than in other disease control group [(529.6 +/- 76.7) micro g/L and (8.3 +/- 2.8) micro g/L respectively] and normal control group [(520.7 +/- 115.9) micro g/L and (5.8 +/- 2.7) micro g/L respectively] (P = 0.000). (2) Correlation analysis showed that there was a positive correlation between the level of serum sICAM-1 and bFGF (r = 0.471, P = 0.000), the level of sICAM-1 was also positively correlated with the number of leukocytes at acute stage (r = 0.285, P = 0.035), and a negative correlation between sICAM-1 and European stroke scale (r = -0.333, P = 0.013) was found. No significant correlation was observed between the level of sICAM-1 and the levels of serum cholesterol (r = -0.042, P = 0.758) or triglyceride (r = 0.061, P = 0.675). (3) Blood pressure seemed to have no influence on the content of sICAM-1 and bFGF after cerebral infarction, while the level of serum bFGF with large infarct size was obviously higher at acute stage.
The levels of sICAM-1 and bFGF increase significantly in the patients with acute cerebral infarction. sICAM-1 and bFGF mayin participate in the pathophysiologic process through inflammatory mechanism. The detection of serum sICAM-1 will be helpful in estimating the clinical severity and the determination of bFGF will be helpful in estimating the size of infarct lesion at acute stage of cerebral infarction.
探讨急性脑梗死患者血清可溶性细胞间黏附分子-1（sICAM-1）和碱性成纤维细胞生长因子（bFGF）水平的变化，以及sICAM-1和bFGF对脑梗死的影响。
采用酶联免疫吸附测定法（ELISA）检测55例急性脑梗死患者（发病2天内）、32例诊断为其他神经系统疾病患者（20例坐骨神经痛患者和12例三叉神经痛患者）及30例健康对照者血清中的sICAM-1和bFGF。
（1）梗死组血清sICAM-1和bFGF水平均显著高于其他疾病对照组[分别为（766.2±178.8）μg/L和（17.4±8.）μg/L]及正常对照组[分别为（529.6±76.7）μg/L和（8.3±2.8）μg/L]（P = 0.000）。（2）相关性分析显示，血清sICAM-1水平与bFGF水平呈正相关（r = 0.471，P = 0.000），sICAM-1水平与急性期白细胞数量也呈正相关（r = 0.285，P = 0.035），且sICAM-1与欧洲卒中量表呈负相关（r = -0.333，P = 0.013）。未观察到sICAM-1水平与血清胆固醇水平（r = -0.042，P = 0.758）或甘油三酯水平（r = 0.061，P = 0.675）之间存在显著相关性。（3）脑梗死发生后血压似乎对sICAM-1和bFGF含量无影响，而梗死面积大的患者急性期血清bFGF水平明显更高。
急性脑梗死患者血清sICAM-1和bFGF水平显著升高。sICAM-1和bFGF可能通过炎症机制参与病理生理过程。检测血清sICAM-1有助于评估临床严重程度，检测血清bFGF有助于评估脑梗死急性期梗死灶大小。
