Belenkii E E, Sokolov I K, Kleimenova N N, Suzdalnitskii R S, Tunitskay T A
Cor Vasa. 1975;17(1):57-65.
The administration of inosine dosed 25 mg/kg daily during 10 1/2 months prevented the development of excentric cardiac hypertrophy on the background of experimental aortic stenosis in rats, reduced the lowering of the working capacity of the animals, and partially inhibited the full development of functional and morphological myocardial changes, detected by electrocardiographic, vectorcardiographic, microscopic, and electronmicroscopic examinations. Differences were found in the relative weights of the heart, thymus, liver and other organs; these findings attested to an anabolic activity of inosine. The results obtained justify the application of inosine for the prevention of excentric hypertrophy and decompensation of the heart in cardiac failures varying in etiology; any efficient preventive measure is of importance, because the degree of excentric hypertrophy is a factor influencing the survival of the patients.
在10个半月的时间里，每天给大鼠按25mg/kg的剂量注射肌苷，可预防实验性主动脉狭窄大鼠出现离心性心肌肥大，降低动物工作能力的下降，并部分抑制通过心电图、向量心电图、显微镜和电子显微镜检查所发现的心肌功能和形态变化的全面发展。在心脏、胸腺、肝脏和其他器官的相对重量上发现了差异；这些发现证明了肌苷的合成代谢活性。所获得的结果证明肌苷可用于预防不同病因心力衰竭中的离心性肥大和心脏失代偿；任何有效的预防措施都很重要，因为离心性肥大的程度是影响患者生存的一个因素。
