七氟醚用于小儿麻醉：氧化亚氮不会增加术后呕吐发生率。
Anaesthesia with sevoflurane in children: nitrous oxide does not increase postoperative vomiting.
作者信息
Bortone Luciano, Picetti Edoardo, Mergoni Mario
机构信息
Department of Anaesthesia and Intensive Care, Azienda Ospedaliera di Parma, Parma, Italy.
出版信息
Paediatr Anaesth. 2002 Nov;12(9):775-9. doi: 10.1046/j.1460-9592.2002.00939.x.
BACKGROUND
Nitrous oxide (N2O) has been associated with postoperative nausea and vomiting (PONV), but some studies show conflicting data. The aim of this study was to assess whether the combination of N2O/sevoflurane, in paediatric general anaesthesia, increases the incidence of vomiting in the 24 h following surgery compared with sevoflurane alone.
METHODS
One hundred and fourteen children, aged 1-10 years, who underwent testicle and inguinal hernia surgery, were randomized to receive one of the following two anaesthetic regimens: sevoflurane with 70% N2O (group A) or sevoflurane alone (group B).
RESULTS
No significant differences were observed in the incidence of postoperative vomiting between the two groups. The overall incidence of postoperative vomiting was 14.9%; 14.3% in group A and 15.5% in group B (P=0.9).
CONCLUSIONS
Nitrous oxide used in combination with sevoflurane is not associated with an increase in the incidence of emesis in children who undergo testicle and inguinal hernia procedures.
背景
氧化亚氮（N₂O）与术后恶心呕吐（PONV）有关，但一些研究显示的数据相互矛盾。本研究的目的是评估在小儿全身麻醉中，与单独使用七氟醚相比，N₂O/七氟醚联合使用是否会增加术后24小时内呕吐的发生率。
方法
114名年龄在1至10岁之间接受睾丸和腹股沟疝手术的儿童被随机分为接受以下两种麻醉方案之一：七氟醚与70% N₂O（A组）或单独使用七氟醚（B组）。
结果
两组术后呕吐发生率无显著差异。术后呕吐的总发生率为14.9%；A组为14.3%，B组为15.5%（P = 0.9）。
结论
在接受睾丸和腹股沟疝手术的儿童中，氧化亚氮与七氟醚联合使用与呕吐发生率增加无关。
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