Manolov S A, Ovcharov V A
Arkh Anat Gistol Embriol. 1976 Jan;70(1):20-3.
The ultrastructural changes found in the endomysium of rats after denervation of the diaphragm and m. plantaris were studied. Within the first week after crossing the peripheral nerve in the nedomysium there appeared an increased amount of neutrophils and monocytes as well as phagocytic material in the cytoplasm of histocytes. Activization of the cytoplasm of fibroblasts which manifested itself in the appearance of numerous vesicles and multiple free and bound ribosomes was detected by the end of the second and the beginning of the third weeks after denervation. At the same period eosinophils invaded the endomysium and became closely surrounded by numerous collagenic fibres. After reparation of neuromuscular synapses these changes disappeared. On the basis of these results and others founded in previous studies of denervated and reinnervated skeletal muscles the authors consider these changes in the endomysium appearing under the above experimental conditions to be manifestations of metabolic interrelations between the endomysium connective tissue and muscle fibres.
对大鼠膈神经和跖肌去神经支配后肌内膜的超微结构变化进行了研究。在膈神经和跖肌去神经支配后的第一周内，肌内膜中出现了数量增加的中性粒细胞和单核细胞，以及组织细胞胞质中的吞噬物质。在去神经支配后的第二周结束和第三周开始时，检测到成纤维细胞胞质的活化，表现为出现大量小泡以及多个游离和附着的核糖体。同期，嗜酸性粒细胞侵入肌内膜，并被大量胶原纤维紧密包围。神经肌肉突触修复后，这些变化消失。基于这些结果以及之前对去神经支配和重新支配的骨骼肌研究中发现的其他结果，作者认为在上述实验条件下肌内膜出现的这些变化是肌内膜结缔组织与肌纤维之间代谢相互关系的表现。
