Akhund Laila, Quinet Robert J, Ishaq Saliha
Department of Internal Medicine, Section on Rheumatology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA.
Arch Intern Med. 2003 Jan 13;163(1):114-5. doi: 10.1001/archinte.163.1.114.
Selective cyclooxygenase 2 (COX-2) inhibitors are known to affect renal prostaglandins (epoprostenol and dinoprostone), which are at least in part COX-2 dependent. Consequently, adverse events including hypertension, peripheral edema, hypercalemia, hyponatremia, and acute renal failure have been reported to occur with the new COX-2-specific inhibitors. This case report posits celecoxib as a likely cause of renal papillary necrosis and alerts physicians to the possibility of this additional renal complication with COX-2-specific inhibitors.
