Murray M J, Flessel C P
Biochim Biophys Acta. 1976 Mar 4;425(2):256-61. doi: 10.1016/0005-2787(76)90032-0.
The effects of divalent cations on mixing curves of synthetic polyribonucleotides in solution are described. Manganese and cadmium chlorides at 10(-3) M induce changes suggestive of base mispairing. MnCl2 induces mispairing in complexes formed between both poly(I) and poly(C,U) and poly(I) and poly(C,A) while CdCl2 affects base pairing between poly(I) and poly(C,U) only. By contrast, the chlorides of magnesium and zinc show no mispairing effects with either polymer pair. Manganese and cadmium are both reported carcinogens in animals while magnesium and zinc are not. The possibility that direct metal-nucleic acid interaction may be involved in metal carcinogenesis is discussed.
描述了二价阳离子对溶液中合成聚核糖核苷酸混合曲线的影响。10⁻³M的氯化锰和氯化镉会引起一些变化，表明存在碱基错配。氯化锰在聚（I）与聚（C，U）以及聚（I）与聚（C，A）形成的复合物中诱导错配，而氯化镉仅影响聚（I）与聚（C，U）之间的碱基配对。相比之下，氯化镁和氯化锌对这两种聚合物对均未显示错配效应。锰和镉在动物中均被报道为致癌物，而镁和锌则不是。讨论了直接的金属 - 核酸相互作用可能参与金属致癌作用的可能性。
