Xin S, Zhao J, Wang S
302 Hospital of PLA, Beijing 100039.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1998 Sep;12(3):251-2.
In order to study the significance of expression of Bcl-1 and Bax proteins in the liver tissues, 35 cases of chronic viral hepatitis (CH) were immunohistochemically studied. The results showed that Bcl-2 and Bax were mainly colocated in cytoplasm of the mononuclear cells(MN) in the areas of focal necrosis, bridging necrosis and piecemeal necrosis (PN). Some hepatocytes surrounding these areas expressed Bcl-2 and Bax or expressed Bax only. Pathological examination found that these hepatocytes Suffered from hydropic or acidophilic degeneration. In the severe viral hepatitis, survival hepatocytes also expressed Bcl-2 and Bax. It is suggested that the expression of Bcl-2 and Bax in the liver tissues correlated with the apoptosis of hepatocytes in CH and influenced the progress of severe viral hepatitis.
为研究Bcl-1和Bax蛋白在肝组织中的表达意义，对35例慢性病毒性肝炎（CH）患者进行了免疫组化研究。结果显示，Bcl-2和Bax主要共定位于局灶性坏死、桥接坏死和碎片状坏死（PN）区域的单核细胞（MN）胞质中。这些区域周围的一些肝细胞表达Bcl-2和Bax或仅表达Bax。病理检查发现这些肝细胞发生了水样变性或嗜酸性变性。在重型病毒性肝炎中，存活的肝细胞也表达Bcl-2和Bax。提示肝组织中Bcl-2和Bax的表达与CH中肝细胞凋亡相关，并影响重型病毒性肝炎的进展。
