老年人癫痫

Epilepsy in the elderly.

作者信息

Leppik Ilo E, Birnbaum Angela

机构信息

MINCEP Epilepsy Care, Minneapolis, Minnesota 55416, USA.

出版信息

Semin Neurol. 2002 Sep;22(3):309-20. doi: 10.1055/s-2002-36650.

DOI:10.1055/s-2002-36650

PMID:12528056

Abstract

The elderly are the most rapidly growing segment of our population, and onset of epilepsy is higher in this age group than in any other. With advancing age, there are changes in drug absorption, disposition, and binding. In addition, within the elderly are subgroups: (1) elderly healthy except for epilepsy (EH) and (2) elderly with multiple medical problems (EMMP). This review examines the factors that need to be considered when selecting the appropriate antiepileptic drug (AED) for an elderly person with epilepsy. Both the older and newer AEDs are reviewed.

摘要

老年人是我国人口中增长最快的群体，该年龄组癫痫的发病率高于其他任何年龄组。随着年龄的增长，药物的吸收、代谢和结合会发生变化。此外，老年人还可分为两个亚组：（1）除癫痫外身体健康的老年人（EH）和（2）患有多种疾病的老年人（EMMP）。本综述探讨了为老年癫痫患者选择合适抗癫痫药物（AED）时需要考虑的因素。对新旧AED均进行了综述。