White Nia, Scott Anne, Woods Robert T, Wenger G Clare, Keady John D, Devakumar Manikkarasa
Centre for Social Policy Research and Development, University of Wales, Bangor.
Br J Gen Pract. 2002 Dec;52(485):1002-3.
The Mini-Mental State Examination (MMSE) is used worldwide to assess cognitive status and it has been recommended for use in primary care to detect dementia. In this study, the MMSE was administered during annual health checks for patients over 75 years of age in nine practices by a member of the primary care team. The mean age was 80 years. Of the 709 patients screened, 286 scored at or below the cut-off point, which was set at 26/30 on the MMSE, and they were invited to be assessed further by a researcher, using the well-validated GMS-AGECAT diagnostic system. Eighty-four of these patients refused, 173 were identified as not having dementia, and 29 (14%) were identified as having dementia. These results, with an 86% false-positive rate, raise concerns regarding the utility of the MMSE as a screening instrument for dementia in primary care.
简易精神状态检查表（MMSE）在全球范围内用于评估认知状态，并且已被推荐用于初级保健中以检测痴呆症。在本研究中，由初级保健团队成员在九家医疗机构为75岁以上患者进行年度健康检查时实施MMSE。平均年龄为80岁。在709名接受筛查的患者中，286名得分在MMSE设定的临界值（26/30）及以下，他们被邀请由一名研究人员使用经过充分验证的GMS-AGECAT诊断系统进行进一步评估。这些患者中有84名拒绝，173名被确定没有痴呆症，29名（14%）被确定患有痴呆症。这些结果的假阳性率为86%，引发了对MMSE作为初级保健中痴呆症筛查工具效用的担忧。
