组织因子的表达与前列腺癌的临床特征及血管生成相关。
Expression of tissue factor is associated with clinical features and angiogenesis in prostate cancer.
作者信息
Ohta Shoichiro, Wada Hideo, Nakazaki Takahiro, Maeda Yoshinobu, Nobori Tsutomu, Shiku Hiroshi, Nakamura Shin, Nagakawa Osamu, Furuya Yuzo, Fuse Hideki
机构信息
Department of Urology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Japan.
出版信息
Anticancer Res. 2002 Sep-Oct;22(5):2991-6.
BACKGROUND
Tissue factor (TF), the main initiator of blood coagulation, is involved in cancer metastasis and progression. We examined the role of TF on prostate cancer.
MATERIALS AND METHODS
Immunohistochemical analysis was performed using the anti-TF antibody. Intra-tumoral blood vessels were visualized by staining endothelial cells with CD34 antibody. We examined the expression of TF and the microvessel density (MVD) in 66 biopsy specimens of prostate cancer, in order to investigate the relationship between the expression of TF and the clinicopathology of prostate cancer.
RESULTS
TF antigen was positive in 41 (62%) of the specimens. There were significant differences in TF expression according to the pretreatment prostate specific antigen (PSA) level (p = 0.0193) and bone metastasis (p = 0.0029). MVD was significantly related to bone metastasis (p = 0.0175). TF-positive carcinomas more frequently presented high MVD expressions (p = 0.017) than TF-negative tumors.
CONCLUSION
These results suggest that increased angiogenesis associated with TF expression might cause the metastasis and progression of prostate cancer.
背景
组织因子（TF）是血液凝固的主要启动因子，参与癌症转移和进展。我们研究了TF在前列腺癌中的作用。
材料与方法
使用抗TF抗体进行免疫组织化学分析。通过用CD34抗体对内皮细胞染色来观察肿瘤内血管。我们检测了66例前列腺癌活检标本中TF的表达和微血管密度（MVD），以研究TF表达与前列腺癌临床病理之间的关系。
结果
41例（62%）标本中TF抗原呈阳性。根据治疗前前列腺特异性抗原（PSA）水平（p = 0.0193）和骨转移情况（p = 0.0029），TF表达存在显著差异。MVD与骨转移显著相关（p = 0.0175）。与TF阴性肿瘤相比，TF阳性癌更常表现出高MVD表达（p = 0.017）。
结论
这些结果表明，与TF表达相关的血管生成增加可能导致前列腺癌的转移和进展。
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