Carrillo J F, Celis M A, Cano A M, Barrera J L, Rivas León B
Departamento de Cabeza y Cuello, División de Cirugía, Instituto Nacional de Cancerología, México, D.F. México.
Acta Otorrinolaringol Esp. 2002 Oct;53(8):585-96. doi: 10.1016/s0001-6519(02)78352-0.
Resection of malignant neoplasms invading the anterior cranial base is performed with craniofacial resection (CFR) with acceptable results in complication rates and oncologic outcomes. However, still there are series with major morbidity in up to 40% of patients, and mortality of 5%. A retrospective study was performed to evaluate the results in terms of morbidity, mortality, function and aesthetics using a median fronto orbital flap (MFOF).
The MFOF was used in 28 consecutive patients who presented to the Head and Neck Service from 1992 to 1999, in the Instituto Nacional de Cancerología, Mexico City, and was combined with a superior rhinotomy for en bloc resection of the ethmoid complex in the last 12 cases. 89% of patients had malignant neoplasms.
1 death occurred in this series (3%) and the global morbidity was 35%. Aesthetics and function were good to excellent. Percentages of tumor-free survival for malignant lesions was 76% and 41% at 2 and 5 years follow up, respectively.
CFR is a safe approach for treatment of neoplasms of the anterior skull base. MFOF mobilization decreases complication rates and gives superb exposure for en bloc resection of tumors invading the ethmoidomaxillary complex specially when combined with a superior rhinotomy. A positive impact on quality of life was obtained.
采用颅面联合切除术(CFR)切除侵犯前颅底的恶性肿瘤,并发症发生率和肿瘤学预后结果均可接受。然而,仍有部分系列研究显示,高达40%的患者出现严重并发症,死亡率为5%。本研究采用中位额眶瓣(MFOF)进行回顾性分析,以评估其在发病率、死亡率、功能和美学方面的效果。
1992年至1999年期间,墨西哥城国家癌症研究所头颈科连续28例患者采用MFOF,并在最后12例患者中联合鼻侧切开术整块切除筛窦复合体。89%的患者患有恶性肿瘤。
本系列研究中有1例死亡(3%),总体并发症发生率为35%。美学和功能效果良好至极佳。恶性病变患者在2年和5年随访时的无瘤生存率分别为76%和41%。
CFR是治疗前颅底肿瘤的一种安全方法。MFOF的应用可降低并发症发生率,并为整块切除侵犯筛窦上颌复合体的肿瘤提供极佳的暴露视野,特别是与鼻侧切开术联合应用时。对生活质量产生了积极影响。