Berstein L M, Imianitov E N, Gamaiunova V B, Kovalevskiĭ A Iu, Kuligina E Sh, Belogubova E V, Buslov K G, Karpova M B, Togo A V, Volkov O N, Kovalenko I G, Chernobrovkina A E
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Vopr Onkol. 2002;48(6):673-8.
Initiation and/or promotion of endometrial carcinoma is considered to be associated with estrogens and androgens (androstendione) excess as well as hyperinsulinemia and resistance to insulin. It is possible that certain polymorphisms of the genes involved in steroidogenesis or steroid metabolism contribute to carcinoma susceptibility. In the current study, we compared the role of CYP17 biallelic MspA1) polymorphism in 114 endometrial carcinoma patients and 182 healthy women. According to our data, A2/A2 CYP17 genotype traditionally regarded as "unfavorable" was less frequent in cancer patients than in control which confirmed the results of two previous publications. For the first time, carriers of the genotype were shown to have relatively low levels of blood insulin and C-peptide. No significant difference was found between mean concentrations of testosterone, dehydroepiandrosterone sulfate and those of estradiol in the carriers of various CYP17 genotypes with endometrial cancer. Hence, CYP17 polymorphism which is represented by the "normal" A1/A1 genotype might be a factor of risk for endometrial carcinoma. Since this genetic variety may develop through an unconventional (nonsteroid) pathway, taking relevant preventive measures in high-risk groups should be recommended.
子宫内膜癌的起始和/或进展被认为与雌激素和雄激素（雄烯二酮）过多以及高胰岛素血症和胰岛素抵抗有关。参与类固醇生成或类固醇代谢的某些基因多态性可能会增加患癌易感性。在本研究中，我们比较了114例子宫内膜癌患者和182例健康女性中CYP17双等位基因MspA1)多态性的作用。根据我们的数据，传统上被认为“不利”的A2/A2 CYP17基因型在癌症患者中的出现频率低于对照组，这证实了之前两篇文献的结果。首次发现该基因型携带者的血液胰岛素和C肽水平相对较低。在患有子宫内膜癌的不同CYP17基因型携带者中，睾酮、硫酸脱氢表雄酮和雌二醇的平均浓度之间没有显著差异。因此，以“正常”A1/A1基因型为代表的CYP17多态性可能是子宫内膜癌的一个风险因素。由于这种基因变异可能通过非常规（非类固醇）途径发展，建议在高危人群中采取相关预防措施。
