Maeyama M, Ifuku M, Nakahara K
J Endocrinol. 1975 Jun;65(3):425-8. doi: 10.1677/joe.0.0650425.
Homogenates of cerebral metastatic chorionepithelioma tissue were incubated with labelled dehydroepiandrosterone, pregnenolone or 20alpha-hydroxypregn-4-en-3-one. The metabolites of dehydroepiandrosterone which were isolated and identified were androstenedione, testosterone, oestrone, and oestradiol; no oestriol was detected. The only metabolite of pregnenolone and 20alpha-hydroxypregn-4-en-3-one isolated and identified was progesterone. No conversion of C-21 to C-19 steroids occurred in the metastatic chorionepithelioma tissue.
将脑转移性绒毛膜上皮癌组织匀浆与标记的脱氢表雄酮、孕烯醇酮或20α-羟基孕-4-烯-3-酮一起孵育。分离并鉴定出的脱氢表雄酮代谢产物有雄烯二酮、睾酮、雌酮和雌二醇；未检测到雌三醇。分离并鉴定出的孕烯醇酮和20α-羟基孕-4-烯-3-酮的唯一代谢产物是孕酮。在转移性绒毛膜上皮癌组织中未发生C-21类固醇向C-19类固醇的转化。
