Miyashita Tetsuya, Ogawa Kenichi, Itoh Hideki, Arai Yukiko, Ashidagawa Minako, Uchiyama Munehito, Koide Yasuhiro, Andoh Tomio, Yamada Yoshitsugu
Department of Anesthesiology, Yokohama City University School of Medicine, 3-9, Fukuura, Kanazawa, Yokohama 236-0004, Japan.
Auton Neurosci. 2003 Jan 31;103(1-2):114-20. doi: 10.1016/s1566-0702(02)00259-x.
We investigated the relationship between electroencephalogram (EEG) activity and autonomic nervous system function using spectral analyses of EEG and heart rate variability (HRV) in healthy subjects during sleep. Eleven subjects were enrolled in this study. From EEG, the spectral edge frequencies (SEFs including SEF50, SEF90 and SEF95) were calculated. From electrocardiogram (ECG), the spectral powers of low-frequency band (LF: 0.04-0.15 Hz), high-frequency band (HF: 0.15-0.4 Hz) and the ratio of LF to HF (LF/HF) were calculated. During sleep, each set of data was obtained as the average of a 5-min measurement. We found that SEFs and LF/HF or LF decreased simultaneously and periodically, suggesting simultaneous depression of EEG activity and relative sympathetic activity, and SEFs significantly correlated with LF/HF and LF in all subjects during sleep, but not with HF. The existence of a clear correlation of SEFs with LF or LF/HF may offer a simple approach to estimate the relationship between EEG activity and autonomic nervous system function during sleep.
我们利用健康受试者睡眠期间脑电图（EEG）的频谱分析和心率变异性（HRV），研究了EEG活动与自主神经系统功能之间的关系。本研究招募了11名受试者。通过EEG计算频谱边缘频率（SEF，包括SEF50、SEF90和SEF95）。通过心电图（ECG）计算低频带（LF：0.04 - 0.15Hz）、高频带（HF：0.15 - 0.4Hz）的频谱功率以及LF与HF的比值（LF/HF）。在睡眠期间，每组数据均作为5分钟测量的平均值获取。我们发现SEF与LF/HF或LF同时且周期性地下降，提示EEG活动和相对交感神经活动同时受到抑制，并且在睡眠期间所有受试者中，SEF与LF/HF和LF显著相关，但与HF无关。SEF与LF或LF/HF之间存在明确的相关性，这可能为评估睡眠期间EEG活动与自主神经系统功能之间的关系提供一种简单的方法。
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