Lewis E, Turk J L
J Pathol. 1975 Feb;115(2):111-25. doi: 10.1002/path.1711150207.
The ability of antisera to guinea-pig C3 to inhibit the Arthus and local Shwartzman reactions was studied. They were found to reduce the non-haemorrhagic component of the active and reversed passive Arthus reactions and to delay the appearance of the haemorrhage in the active Arthus reaction. Cobra venom factor, however, had no effect on the non-haemorrhagic components of these reactions and only delayed the appearance of the haemorrhage of the active Arthus reaction. There appeared to be a correlation between the serum complement level and the time taken for the haemorrhage to appear, and between the circulating platelet count and the extent of the non-haemorrhagic, oedematous component of the reaction. The haemorrhagic component of the local Shwartzman reaction was not affected by decomplementation with cobra venom factor. The ability of the antisera to inhibit the haemorrhage of the Shwartzman reaction was not dependent on lowering the serum complement titre. However, the haemorrhage was inhibited if the circulating platelet count was also reduced to very low numbers. Antiserum to zymosan alone had the same effect as anti-beta1C/beta1A globulin (zymosan) in blocking the reaction, although it did not alter the complement levels or the platelet counts. The possibility of an immunological cross-reactivity between zymosan and endotoxin in this action is discussed.
研究了豚鼠C3抗血清抑制阿瑟斯反应和局部施瓦茨曼反应的能力。发现它们可减少主动和反向被动阿瑟斯反应的非出血成分，并延缓主动阿瑟斯反应中出血的出现。然而，眼镜蛇毒因子对这些反应的非出血成分没有影响，仅延缓了主动阿瑟斯反应中出血的出现。血清补体水平与出血出现的时间之间，以及循环血小板计数与反应的非出血性水肿成分的程度之间似乎存在相关性。局部施瓦茨曼反应的出血成分不受眼镜蛇毒因子去补体作用的影响。抗血清抑制施瓦茨曼反应出血的能力并不取决于降低血清补体滴度。然而，如果循环血小板计数也降至非常低的水平，则出血会受到抑制。单独的酵母聚糖抗血清在阻断反应方面与抗β1C/β1A球蛋白（酵母聚糖）具有相同的效果，尽管它不会改变补体水平或血小板计数。讨论了酵母聚糖和内毒素在该作用中发生免疫交叉反应的可能性。
