眼镜蛇毒因子未能预防全身性施瓦茨曼反应及肾皮质纤溶活性丧失。
Failure of cobra venom factor to prevent the generalized Shwartzman reaction and loss of renal cortical fibrinolytic activity.
作者信息
Bergstein J M, Michael A F
出版信息
Am J Pathol. 1974 Jan;74(1):19-31.
Abstract
Previous studies have shown that renal cortical fibrinolytic activity is absent in rabbits given one or two injections of endotoxin. Using a fibrin slide technic, we have studied the effect of endotoxin on cortical fibrinolytic activity in rabbits depleted of terminal complement components (C3-C9) by cobra venom factor. The loss of cortical fibrinolytic activity induced by endotoxin is not prevented by pretreatment with cobra venom factor. Additionally, this complement depletion did not prevent development of glomerular fibrin deposition, cortical necrosis or thrombocytopenia in the generalized Shwartzman reaction.
摘要
先前的研究表明，给兔子注射一或两次内毒素后，其肾皮质的纤维蛋白溶解活性会消失。我们采用纤维蛋白玻片技术，研究了内毒素对经眼镜蛇毒因子消耗终末补体成分（C3 - C9）的兔子皮质纤维蛋白溶解活性的影响。眼镜蛇毒因子预处理并不能阻止内毒素诱导的皮质纤维蛋白溶解活性丧失。此外，这种补体耗竭并不能阻止全身性施瓦茨曼反应中肾小球纤维蛋白沉积、皮质坏死或血小板减少的发生。
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本文引用的文献
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J Exp Med. 1971 Sep 1;134(3 Pt 1):642-55. doi: 10.1084/jem.134.3.642.
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