通过定量外周血中自身反应性T细胞预测非肥胖糖尿病（NOD）小鼠的自发性自身免疫性糖尿病
Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood.
作者信息
Trudeau Jacqueline D, Kelly-Smith Carolyn, Verchere C Bruce, Elliott John F, Dutz Jan P, Finegood Diane T, Santamaria Pere, Tan Rusung
机构信息
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
J Clin Invest. 2003 Jan;111(2):217-23. doi: 10.1172/JCI16409.
Abstract
Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing pancreatic beta cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by direct detection of autoreactive T cells in peripheral blood has proved elusive, in part because of their low frequency and reduced avidity for peptide MHC ligands. This article was published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org.
摘要
自身免疫性（1型）糖尿病是由T淋巴细胞破坏产生胰岛素的胰腺β细胞所致。通过直接检测外周血中的自身反应性T细胞来预测细胞介导的自身免疫性疾病已被证明难以实现，部分原因是它们的频率较低且对肽MHC配体的亲和力降低。本文已先于印刷版在线发表。发布日期可从JCI网站获取，网址为http://www.jci.org。
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