Obayashi K, Mandel W J
Cardiovasc Res. 1976 Jan;10(1):20-4. doi: 10.1093/cvr/10.1.20.
The electrophysiological effects of increasing molar concentrations of ajmaline were studied in isolated cardiac tissue, including sino-atrial node and Purkinje fibre. Ajmaline produced significant shortening of the plateau of Purkinje fibre action potential associated with marked depression of dV/dt and directly measured conduction velocity. A negative chronotropic effect was noted both in the sinus node and in spontaneously beating Purkinje fibres. Ajmaline's major electrophysiological effect appears to be depression of Purkinje fibre conduction velocity.
在离体心脏组织（包括窦房结和浦肯野纤维）中研究了增加阿吗灵摩尔浓度时的电生理效应。阿吗灵可使浦肯野纤维动作电位平台期显著缩短，同时伴有dV/dt的明显降低以及直接测量的传导速度下降。在窦房结和自发搏动的浦肯野纤维中均观察到负性变时效应。阿吗灵的主要电生理效应似乎是降低浦肯野纤维的传导速度。
