Use of small samples of urine to monitor testicular response to human chorionic gonadotropin.

The increased urinary excretion of androsterone and aetiocholanolone, 17-oxosteroids, and oestrogens which occurs after the administration of human chorionic gonadotropin to normal men, was followed by measuring steroid to creatinine ratios in small samples of urine. For androsterone + aetiocholanolone, values of the ratio correspond closely with 24 h output (correlation coefficients: 0.91, 0.92, and 0.91 for first morning, mid-morning, and mid-afternoon urine specimens.) Comparable correlation coefficients for the 17-oxosteroids in urine were 0.90, 0.95, and 0.91; and for oestrogens, 0.88, 0.87, and 0.86.