双酚F二缩水甘油醚异构体在豚鼠体内的致敏能力及交叉反应模式
Sensitizing capacity and cross-reaction pattern of the isomers of diglycidyl ether of bisphenol F in the guinea pig.
作者信息
Pontén A, Zimerson E, Sörensen O, Bruze M
机构信息
Department of Occupational and Environmental Dermatology, Malmö University Hospital, Malmö, Sweden.
出版信息
Contact Dermatitis. 2002 Nov;47(5):293-8. doi: 10.1034/j.1600-0536.2002.470507.x.
In this study, the sensitizing capacities of the 3 main low-molecular-weight isomers of epoxy resins based on diglycidyl ether of biphenol F (DGEBF) were investigated in a guinea pig maximization test (GPMT). The isomers are p,p'-DGEBF, o,p'-DGEBF, and o,o'-DGEBF. The sensitization capacities were compared to diglycidyl ether of bisphenol A (DGEBA), which is the main constituent in the most common epoxy resin. The cross-reaction pattern between all 4 compounds was also investigated. It was found that all 3 DGEBF isomers were potent sensitizers. It was also found that p,p'-DGEBF, o,p'-DGEBF, and DGEBA cross-reacted with one another, and that animals induced with o,o'-DGEBF reacted significantly only to o,p'-DGEBF, but not to the other 2 DGEBF isomers or DGEBA.
在本研究中，基于双酚F二缩水甘油醚（DGEBF）的3种主要低分子量环氧树脂异构体的致敏能力在豚鼠最大化试验（GPMT）中进行了研究。这些异构体为对，对'-DGEBF、邻，对'-DGEBF和邻，邻'-DGEBF。将致敏能力与双酚A二缩水甘油醚（DGEBA）进行了比较，DGEBA是最常见环氧树脂中的主要成分。还研究了所有4种化合物之间的交叉反应模式。结果发现，所有3种DGEBF异构体都是强效致敏剂。还发现，对，对'-DGEBF、邻，对'-DGEBF和DGEBA之间会发生交叉反应，并且用邻，邻'-DGEBF诱导的动物仅对邻，对'-DGEBF有显著反应，而对其他2种DGEBF异构体或DGEBA无反应。
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