Fernandes Isabelle, Bastien Yolande, Wai Timothy, Nygard Karen, Lin Roberto, Cormier Olivier, Lee Han S, Eng Frankie, Bertos Nicholas R, Pelletier Nadine, Mader Sylvie, Han Victor K M, Yang Xiang-Jiao, White John H
Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6.
Mol Cell. 2003 Jan;11(1):139-50. doi: 10.1016/s1097-2765(03)00014-5.
LCoR (ligand-dependent corepressor) is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LXXLL motif. LCoR binding to estrogen receptor alpha depends in part on residues in the coactivator binding pocket distinct from those bound by TIF-2. Repression by LCoR is abolished by histone deacetylase inhibitor trichostatin A in a receptor-dependent fashion, indicating HDAC-dependent and -independent modes of action. LCoR binds directly to specific HDACs in vitro and in vivo. Moreover, LCoR functions by recruiting C-terminal binding protein corepressors through two consensus binding motifs and colocalizes with CtBPs in the nucleus. LCoR represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms.
配体依赖性共抑制因子（LCoR）是一种转录共抑制因子，在胎儿和成人组织中广泛表达，它通过单个LXXLL基序被招募到与激动剂结合的核受体上。LCoR与雌激素受体α的结合部分取决于共激活因子结合口袋中与TIF-2结合位点不同的残基。组蛋白去乙酰化酶抑制剂曲古抑菌素A以受体依赖的方式消除了LCoR的抑制作用，表明其存在依赖和不依赖组蛋白去乙酰化酶的作用模式。LCoR在体外和体内均直接与特定的组蛋白去乙酰化酶结合。此外，LCoR通过两个共有结合基序招募C末端结合蛋白共抑制因子发挥作用，并与CtBPs在细胞核中共定位。LCoR代表了一类通过多种机制减弱激动剂激活的核受体信号传导的共抑制因子。
