Kastin Abba J, Pan Weihong, Akerstrom Victoria, Hackler Laszlo, Wang Chuanfeng, Kotz Catherine M
Veterans Affairs Medical Center and Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA 70112-1262, USA.
Peptides. 2002 Dec;23(12):2189-96. doi: 10.1016/s0196-9781(02)00247-4.
There is need for a new approach to the suppression of feeding. Here, we show that two of the most potent endogenous satiety peptides interact in a novel way to cross the blood-brain barrier (BBB) and to suppress food intake. Combined peripheral administration of leptin and urocortin (UCN) significantly decreased food intake, whereas neither one showed an effect when given alone in the same doses. We further provide a mechanism whereby this novel cooperativity can occur by demonstrating that UCN, which by itself does not cross the BBB, can readily enter the brain by associating with leptin. Such a novel interaction between two peptides at the BBB opens new approaches for general study of the dynamic regulatory role of the BBB in brain-body communication as well as the specific study of obesity.
需要一种新的抑制进食的方法。在此，我们表明两种最有效的内源性饱腹感肽以一种新的方式相互作用，穿过血脑屏障（BBB）并抑制食物摄入。联合外周给予瘦素和尿皮质素（UCN）可显著减少食物摄入量，而单独给予相同剂量时，两者均无效果。我们进一步提供了一种机制，通过证明自身不能穿过血脑屏障的UCN可通过与瘦素结合而轻易进入大脑，从而说明这种新的协同作用是如何发生的。血脑屏障处两种肽之间的这种新型相互作用为全面研究血脑屏障在脑-体通讯中的动态调节作用以及肥胖症的具体研究开辟了新途径。
