Tu Q Y, Tang X Q, Liu Z Q
Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Hunan Yi Ke Da Xue Xue Bao. 2001 Aug 28;26(4):331-4.
To study the variation of nitric oxide synthase (NOS) neurons in rats with learning-remembering barrier by immunohistochemistry and histochemistry. The number of NOS neurons decreased apparently in hippocampus CA1-4 of rats with learning-remembering barrier, there were lots of new NOS neurons in dentate gyrus granular cell grays and pear-shaped zone's cortex. It is suggested that NOS neurons of hippocampus exert very important action in rat's learning remembering; new NOS neurons in pear-shaped zone cortex and dentate gyrus granular cell grays may be a compensative reaction of the learning-remembering barrier, and they might exert important function in following recovery of learning-remembering function.
采用免疫组织化学和组织化学方法研究学习记忆障碍大鼠一氧化氮合酶（NOS）神经元的变化。学习记忆障碍大鼠海马CA1 - 4区NOS神经元数量明显减少，齿状回颗粒细胞层和梨状区皮质有大量新的NOS神经元。提示海马NOS神经元在大鼠学习记忆中发挥非常重要的作用；梨状区皮质和齿状回颗粒细胞层新的NOS神经元可能是学习记忆障碍的一种代偿反应，它们可能在随后学习记忆功能的恢复中发挥重要作用。
