Bailis Julie M, Forsburg Susan L
Molecular and Cellular Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Genome Biol. 2002;3(12):REVIEWS1035. doi: 10.1186/gb-2002-3-12-reviews1035. Epub 2002 Nov 28.
Repeated DNA elements and region-specific protein modifications combine within chromosomes to form a transcriptionally silent chromatin structure called heterochromatin. Recent work in the fission yeast Schizosaccharomyces pombe reveals that RNA is also an integral component of silent heterochromatin, providing a new perspective on how heterochromatin is organized and maintained in eukaryotic cells.
重复DNA元件和区域特异性蛋白质修饰在染色体内结合，形成一种称为异染色质的转录沉默染色质结构。裂殖酵母粟酒裂殖酵母的最新研究表明，RNA也是沉默异染色质的一个组成部分，为真核细胞中异染色质的组织和维持方式提供了新的视角。
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