Hannon Gregory J
Cold Spring Harbour Laboratory, New York 11724, USA.
Nature. 2002 Jul 11;418(6894):244-51. doi: 10.1038/418244a.
A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.
一种对双链RNA保守的生物学反应,有多种名称,如RNA干扰(RNAi)或转录后基因沉默,介导对内源寄生性和外源致病性核酸的抗性,并调节蛋白质编码基因的表达。RNAi已被开发为一种在实验上操纵基因表达并在全基因组范围内探究基因功能的手段。