Liu H, Zheng L, Yu S
Department of Pathology, Affiliated Beijing Tongren Hospital of Capital University of Medical Sciences.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2000 Apr;18(2):103-5.
To prove further the pathological classification of Melkersson-Rosenthal syndrome (MRS) and observe the morphological features of the granuloma cells in MRS.
We studied 20 cases of MRS, with 10 cases of granuloma type and the other 10 cases of non-granuloma type. The negative results of periodic acid-schiff (PAS), Neelren anti-acid special staining and tuberculosis (TB)-DNA polymerase chain reaction proved that all cases were not TB and fungous disease. Then all the cases were labelled with antibody of lysozyme by immunohistochemical staining and investigated with electron microscope. We studied the expression of lysozyme in multinucleated giant cells, epithelioid cells and histiocytes.
The results of lysozyme staining were positive in the multinucleated giant cells, epithelioid cells and histiocytes of the granuloma type and were negative in those cells of the non-granuloma type. On the other hand, the small multinucleated giant cells which had 2-3 nuclei were the features of the morphological structure of the granuloma type. The small multinucleated giant cells were not seen in the non-granuloma type.
In this paper, two pathological types (granuloma and non-granuloma type) in the MRS were proved further and it is found that the different structures of granuloma can be used to discriminate between MRS and sarcoidosis and tuberculosis.
进一步证实梅尔克森 - 罗森塔尔综合征（MRS）的病理分类，并观察MRS中肉芽肿细胞的形态特征。
我们研究了20例MRS患者，其中10例为肉芽肿型，另外10例为非肉芽肿型。过碘酸 - 希夫（PAS）、尼尔伦抗酸特殊染色及结核（TB） - DNA聚合酶链反应的阴性结果证明所有病例均非结核和真菌病。然后通过免疫组织化学染色用溶菌酶抗体对所有病例进行标记，并用电镜进行观察。我们研究了溶菌酶在多核巨细胞、上皮样细胞和组织细胞中的表达。
肉芽肿型的多核巨细胞、上皮样细胞和组织细胞中溶菌酶染色结果为阳性，而非肉芽肿型的这些细胞中溶菌酶染色结果为阴性。另一方面，具有2 - 3个核的小多核巨细胞是肉芽肿型的形态结构特征。非肉芽肿型中未见小多核巨细胞。
本文进一步证实了MRS的两种病理类型（肉芽肿型和非肉芽肿型），并且发现肉芽肿的不同结构可用于鉴别MRS与结节病和结核病。
