面向生物学家的本体论：基因本体论——理清脉络

On ontologies for biologists: the Gene Ontology--untangling the web.

作者信息

Ashburner Michael, Lewis Suzanna

机构信息

Department of Genetics, University of Cambridge and EMBL--European Bioinformatics Institute, Hinxton, Cambridge, UK.

出版信息

Novartis Found Symp. 2002;247:66-80; discussion 80-3, 84-90, 244-52.

PMID:12539950

Abstract

The mantra of the 'post-genomic' era is 'gene function'. Yet surprisingly little attention has been given to how functional and other information concerning genes is to be captured, made accessible to biologists or structured in a computable form. The aim of the Gene Ontology (GO) Consortium is to provide a framework for both the description and the organisation of such information. The GO Consortium is presently concerned with three structured controlled vocabularies which can be used to describe three discrete biological domains, building structured vocabularies which can be used to describe the molecular function, biological roles and cellular locations of gene products.

摘要

“后基因组”时代的口头禅是“基因功能”。然而，令人惊讶的是，对于如何获取有关基因的功能及其他信息、如何让生物学家能够获取这些信息以及如何以可计算的形式进行构建，却很少有人关注。基因本体论（GO）联盟的目标是为这类信息的描述和组织提供一个框架。GO联盟目前关注三个结构化的控制词汇表，这些词汇表可用于描述三个不同的生物领域，构建可用于描述基因产物的分子功能、生物学作用和细胞定位的结构化词汇表。