基因本体注释的使用与误用。

Use and misuse of the gene ontology annotations.

作者信息

Rhee Seung Yon, Wood Valerie, Dolinski Kara, Draghici Sorin

机构信息

Carnegie Institution for Science, Department of Plant Biology, 260 Panama Street, Stanford, California 94305, USA.

出版信息

Nat Rev Genet. 2008 Jul;9(7):509-15. doi: 10.1038/nrg2363. Epub 2008 May 13.

DOI:10.1038/nrg2363

PMID:18475267

Abstract

The Gene Ontology (GO) project is a collaboration among model organism databases to describe gene products from all organisms using a consistent and computable language. GO produces sets of explicitly defined, structured vocabularies that describe biological processes, molecular functions and cellular components of gene products in both a computer- and human-readable manner. Here we describe key aspects of GO, which, when overlooked, can cause erroneous results, and address how these pitfalls can be avoided.

摘要

基因本体论（GO）项目是模式生物数据库之间的一项合作，旨在使用一种一致且可计算的语言来描述所有生物的基因产物。GO生成了一套明确界定的结构化词汇集，以计算机可读和人类可读的方式描述基因产物的生物学过程、分子功能和细胞成分。在这里，我们描述了GO的关键方面，这些方面若被忽视可能会导致错误结果，并探讨了如何避免这些陷阱。