Chavakis Triantafyllos, Preissner Klaus T, Santoso Sentot
Department of Medicine 1, University Hospital, Heidelberg, Germany.
Thromb Haemost. 2003 Jan;89(1):13-7.
The molecular details of leukocyte transmigration through the endothelial barrier (also called diapedesis), which is the final step of leukocyte extravasation from the circulation to a given site of inflammation, are by far not well understood. The present review will focus on the different mechanisms potentially involved in leukocyte trans-endothelial migration. Both homophilic and heterophilic interactions between leukocyte and endothelial cell receptors will be covered, with a particular focus on the growing gene family of junctional adhesion molecules (JAM). Deciphering their mechanisms of interaction will also allow to unravel novel strategies for therapeutic intervention in inflammatory or atherothrombotic diseases.
白细胞通过内皮屏障（也称为渗出）的分子细节，这是白细胞从循环系统外渗到特定炎症部位的最后一步，目前还远未被充分理解。本综述将聚焦于白细胞跨内皮迁移可能涉及的不同机制。将涵盖白细胞与内皮细胞受体之间的同嗜性和异嗜性相互作用，特别关注不断增加的连接粘附分子（JAM）基因家族。解读它们的相互作用机制也将有助于揭示针对炎症或动脉粥样硬化血栓形成疾病进行治疗干预的新策略。
