Schultze Jürgen, Reinke Constantin, Frese Knut Arvid, Kimmig Bernhard
Klinik für Strahlentherapie (Radioonkologie), Universitätsklinikum Kiel, Germany.
Strahlenther Onkol. 2003 Jan;179(1):31-7. doi: 10.1007/s00066-003-1026-z.
The treatment results of symptomatic radiation therapy of the Eustachian tube in chronic otitis media had to be evaluated retrospectively.
Between 1980 and 1997, 66 patients were referred for therapy. The median age was 58 years. In the clinical presentation, all the patients had a hearing impairment, 35 patients complained of pain, 21 had otorrhea. In their history, 20 patients indicated chronic recurrent infections. The complaints lasted for 4.7 years in the median, primary conservative (adstringentia, antibiotics) and surgical treatment (paracentesis, tympanic tubule, tympanoplastic) did not lead to lasting cure. In 40 of 66 patients, finally radiation therapy was done of both Eustachian tubes. With opposed fields and cobalt-60 photons a total dose of 6 Gy at single doses of 1 Gy, three times a week, was applied. Under the causes for exclusion of radiation therapy were non-acceptance of the patients (nine), prior radiation therapies (six) or spontaneous improvement after initial presentation in our department. The treatment results were evaluated by interviews of the patients and regular otorhinolaryngological examinations.
There were no side effects noticed. 28 of 40 (70%) patients reported a significant improvement that could be verified by objective otorhinolaryngological examinations. In the group of 26 nonirradiated patients, 22 could be interviewed indicating in 16 cases (72%) that the complaints were unchanged and chronic otitis media was lasting. In a subgroup analysis concerning the duration of otitis media radiation therapy proved more effective in an acute and subacute stadium of disease of up to 5 years duration, while the patients resistant to radiation therapy were entirely in a chronic stage of disease exceeding 5 years duration.
Radiation therapy is an effective tool for symptomatic improvement of the therapy-resistant chronic otitis media. A dose of 6 Gy seems to be sufficient to achieve an antiinflammatory effect. Radiotherapy should be applied earlier after initial conservative and surgical treatment.
必须对慢性中耳炎咽鼓管症状性放射治疗的结果进行回顾性评估。
1980年至1997年间,66例患者前来接受治疗。中位年龄为58岁。临床表现方面,所有患者均有听力障碍,35例患者主诉疼痛,21例有耳漏。病史方面,20例患者表示有慢性复发性感染。这些症状的持续时间中位值为4.7年,初次保守治疗(收敛剂、抗生素)和手术治疗(穿刺、鼓膜小管、鼓室成形术)均未带来持久治愈。66例患者中有40例最终对双侧咽鼓管进行了放射治疗。采用对穿野和钴 - 60光子,每周三次,每次1 Gy,总剂量6 Gy。排除放射治疗的原因包括患者不接受(9例)、既往有放射治疗史(6例)或在我科初次就诊后症状自发改善。通过对患者的访谈和定期耳鼻喉科检查来评估治疗结果。
未观察到副作用。40例患者中有28例(70%)报告有明显改善,这可通过客观的耳鼻喉科检查得到证实。在26例未接受放射治疗的患者组中,有22例接受了访谈,其中16例(72%)表示症状未改变,慢性中耳炎持续存在。在关于中耳炎病程的亚组分析中,放射治疗在病程长达5年的急性和亚急性阶段更有效,而对放射治疗有抵抗的患者完全处于病程超过5年的慢性阶段。
放射治疗是改善难治性慢性中耳炎症状的有效手段。6 Gy的剂量似乎足以产生抗炎效果。放射治疗应在初次保守和手术治疗后尽早应用。