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一项针对自闭症学龄前儿童的家长培训干预措施的试点随机对照试验。初步结果及方法学挑战。

A pilot randomised control trial of a parent training intervention for pre-school children with autism. Preliminary findings and methodological challenges.

作者信息

Drew Auriol, Baird Gillian, Baron-Cohen Simon, Cox Antony, Slonims Vicky, Wheelwright Sally, Swettenham John, Berry Bryony, Charman Tony

机构信息

Autism Research Centre, Departments of Experimental Psychology and Psychiatry, University of Cambridge, Cambridge, UK.

出版信息

Eur Child Adolesc Psychiatry. 2002 Dec;11(6):266-72. doi: 10.1007/s00787-002-0299-6.

Abstract

Few attempts have been made to conduct randomised control trials (RCTs) of interventions for pre-school children with autism. We report findings of a pilot RCT for a parent training intervention with a focus on the development of joint attention skills and joint action routines. Twenty-four children meeting ICD-10 criteria for childhood autism (mean age = 23 months) were identified using the CHAT screen and randomised to the parent training group or to local services only. A follow-up was conducted 12 months later (mean age = 35 months). There was some evidence that the parent training group made more progress in language development than the local services group. However, the present pilot study was compromised by several factors: a reliance on parental report to measure language, non-matching of the groups on initial IQ, and a lack of systematic checking regarding the implementation of the parent training intervention. Furthermore, three parents in the local services group commenced intensive, home-based behavioural intervention during the course of the study. The difficulties encountered in the conduct of RCTs for pre-school children with autism are discussed. Methodological challenges and strategies for future well-designed RCTs for autism interventions are highlighted.

摘要

很少有人尝试对自闭症学龄前儿童的干预措施进行随机对照试验(RCT)。我们报告了一项试点随机对照试验的结果,该试验是一项针对家长的培训干预措施,重点是培养共同注意技能和共同行动常规。使用CHAT筛查工具确定了24名符合ICD - 10儿童自闭症标准的儿童(平均年龄 = 23个月),并将他们随机分为家长培训组或仅接受当地服务组。12个月后进行了随访(平均年龄 = 35个月)。有证据表明,家长培训组在语言发展方面比当地服务组取得了更大的进步。然而,目前的试点研究受到几个因素的影响:依赖家长报告来衡量语言能力、两组在初始智商上不匹配,以及缺乏对家长培训干预措施实施情况的系统检查。此外,当地服务组的三名家长在研究过程中开始了强化的家庭行为干预。讨论了在自闭症学龄前儿童随机对照试验中遇到的困难。强调了未来设计良好的自闭症干预随机对照试验的方法学挑战和策略。

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