反相高效液相色谱法测定盐酸索他洛尔
[Determination of sotalol hydrochloride by reversed-phase high performance liquid chromatography].
作者信息
Wang W H, Zhao G S, Jiang W L, Zuo A X, Bi H T
机构信息
College of Pharmacy, Shandong Medical University, Jinan 250062, China.
出版信息
Se Pu. 2000 Mar;18(2):178-80.
An RP-HPLC method for determination and detection of sotalol hydrochloride is described. The baseline separation was achieved on ODS column within 15 minutes by using 0.1% HAc-acetonitrile (80:20, V/V) as mobile phase at a flow rate 1.5 mL/min, and the wavelength was set at 227 nm. The linear range was 5-45 mg/L (r = 0.9991) and the limit of detection was 1 mg/L(S/N > 3). The intra-day and inter-day RSDs were 0.20% and 0.93% respectively.
描述了一种用于测定和检测盐酸索他洛尔的反相高效液相色谱法。使用0.1%乙酸-乙腈（80:20，V/V）作为流动相，流速为1.5 mL/min，在ODS柱上15分钟内实现了基线分离，波长设定为227 nm。线性范围为5-45 mg/L（r = 0.9991），检测限为1 mg/L（S/N > 3）。日内和日间相对标准偏差分别为0.20%和0.93%。
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