阳离子介导的bastadin - 4还原为bastadin - 5。通过位点特异性同位素标记制备5 - [2H] - bastadin - 5。

Cationic reduction of bastadin-4 to bastadin-5. Preparation of 5-[2h]-bastadin-5 by site-specific isotopic labeling.

作者信息

Masuno Makoto N, Molinski Tadeusz F

机构信息

Department of Chemistry, One Shields Avenue, University of California, Davis, California 95616, USA.

出版信息

J Nat Prod. 2003 Jan;66(1):112-4. doi: 10.1021/np020382h.

DOI:10.1021/np020382h

PMID:12542356

Abstract

A chemoselective conversion of bastadin-4 to the important Ca2+ channel modulator bastadin-5 (1a) has been achieved using cationic hydrogenation (Et3SiH, TFA, 60%). Specifically deuterated bastadin-5 (1b, >95 at. %) was prepared following this method and the simplified 1H NMR H-5/H2-6 spin system of 1b exploited to study temperature-dependent macrocyclic ring dynamics.

摘要

使用阳离子氢化反应（三乙基硅烷、三氟乙酸，产率60%）已实现了将bastadin - 4化学选择性转化为重要的Ca2+通道调节剂bastadin - 5（1a）。按照此方法制备了特定氘代的bastadin - 5（1b，氘含量>95原子%），并利用1b简化的1H NMR H - 5/H2 - 6自旋系统研究温度依赖性大环环动力学。