来自巴氏软珊瑚的bastadin 20和bastadin O - 硫酸酯：Ry1R FKBP12受体复合物的新型调节剂。
Bastadin 20 and bastadin O-sulfate esters from Ianthella basta: novel modulators of the Ry1R FKBP12 receptor complex.
作者信息
Franklin M A, Penn S G, Lebrilla C B, Lam T H, Pessah I N, Molinski T F
机构信息
Department of Chemistry, University of California, Davis 95616, USA.
出版信息
J Nat Prod. 1996 Dec;59(12):1121-7. doi: 10.1021/np960507g.
New compounds bastadin 20 (9), 15,34-O-disulfatobastadin 7 (10), and 10-O-sulfatobastadin 3 (11) were isolated from Ianthella basta collected in Exmouth Gulf, Western Australia. Compounds 10 and 11 exhibited moderate differential activity as SR Ca2+ channel agonists (EC50 13.6 and 100 microM, respectively) of the Ry1R FKBP12 complex, while the potency of 9 was almost half that of 10 (EC50 20.6 microM). The problem of dereplication of bastadins was addressed using 1H-NMR "fingerprinting" of MeO signals in the corresponding permethyl bastadin derivatives.
从采集于西澳大利亚埃克斯茅斯湾的巴氏软珊瑚（Ianthella basta）中分离出了新化合物bastadin 20（9）、15,34 - O - 二硫酸化bastadin 7（10）和10 - O - 硫酸化bastadin 3（11）。化合物10和11作为兰尼碱受体1（Ry1R）FKBP12复合物的肌浆网Ca2+通道激动剂表现出中等程度的差异活性（EC50分别为13.6和100微摩尔），而化合物9的效力几乎是化合物10的一半（EC50为20.6微摩尔）。利用相应全甲基化bastadin衍生物中MeO信号的1H - NMR“指纹图谱”解决了bastadins的重复鉴定问题。
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