Gorski David H, Mauceri Helena J, Salloum Rabih M, Halpern Arielle, Seetharam Saraswathy, Weichselbaum Ralph R
Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637, USA.
Cancer Res. 2003 Jan 15;63(2):308-11.
Ionizing radiation (IR) and concomitant angiostatin (AS) produce greater than additive local antitumor effects. We examined whether prolonged AS treatment added to IR reduces proliferation of lung metastases from LLC primary tumors. Flank tumors were treated with 40 Gy with or without AS (25 mg/kg/day). IR plus a 14-day course of AS improved local tumor control and blocked the increase in lung weights observed in the group receiving IR plus a 2-day course of AS group. Animals treated with prolonged AS exhibited no increase in lung weight and no macrometastases. These findings suggest that long-term treatment with antiangiogenic compounds may be effective in preventing metastases from IR-treated tumors as well as increasing the local antitumor effects of radiotherapy.
