Vα14 NKT细胞在固有免疫和获得性免疫应答中的调节作用。
The regulatory role of Valpha14 NKT cells in innate and acquired immune response.
作者信息
Taniguchi Masaru, Harada Michishige, Kojo Satoshi, Nakayama Toshinori, Wakao Hiroshi
机构信息
Laboratory of Immune Regulation, RIKEN Research Center for Allergy and Immunology, Chuo-ku, Chiba 260-8670, Japan.
出版信息
Annu Rev Immunol. 2003;21:483-513. doi: 10.1146/annurev.immunol.21.120601.141057. Epub 2001 Dec 19.
A novel lymphocyte lineage, Valpha14 natural killer T (NKT) cells, is now well established as distinct from conventional alphabeta T cells. Valpha14 NKT cells express a single invariant Valpha14 antigen receptor that is essential for their development. Successful identification of a specific ligand, alpha-galactosylceramide(alpha-GalCer), and the establishment of gene-manipulated mice with selective loss of Valpha14 NKT cells helped elucidate the remarkable functional diversity of Valpha14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.
一种新型淋巴细胞谱系，即Vα14自然杀伤T（NKT）细胞，现已明确与传统的αβ T细胞不同。Vα14 NKT细胞表达单一恒定的Vα14抗原受体，这对其发育至关重要。成功鉴定出特异性配体α-半乳糖神经酰胺（α-GalCer），以及建立Vα14 NKT细胞选择性缺失的基因操作小鼠，有助于阐明Vα14 NKT细胞在各种免疫反应中的显著功能多样性，如通过介导抗非己固有免疫反应进行宿主防御、抗自身反应的稳态调节以及抗肿瘤免疫。
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