The effect of some drugs on the urinary excretion of some aryl alkyl amines in the rat.

The urinary excretion levels of meta tyramine (mTA), para tyramine (pTA) and beta-phenylethylamine (PE) in the untreated rat have been established. The effects of intraperitoneal injections of a precursor (L-Dopa) and some inhibitors of monoamine oxidation (pargyline), decarboxylation (Ro4-4602) and hydroxylation (iprindole, imipramine and para chlorophenylalanine (PCPA) are consistent with the interpretation that PE arises essentially as a result of decarboxylation of phenylalanine, pTA by hydroxylation of PE and mTA by dehydroxylation (and decarboxylation) of a catechol.