Boulton A A, Juorio A V
Experientia. 1983 Feb 15;39(2):130-4. doi: 10.1007/BF01958860.
The decarboxylase inhibitor DL-alpha-monofluoromethyldopa reduces, in a dose dependent manner, the concentration of striatal p-tyramine in the mouse. Homovanillic acid is also significantly reduced. Conversely, this treatment increases the m-tyramine concentration. Administration of m-tyrosine produces large increases in m-tyramine and a slight decrease in p-tyramine; these changes are potentiated in the presence of the decarboxylase inhibitor. Such data along with other recently published results permit the conclusion that m-tyramine arises from phenylalanine via m-tyrosine and that p-tyramine arises by decarboxylation of p-tyrosine. Both these reactions are closely related to the activity of tyrosine hydroxylase and the availability of appropriate substrates.
脱羧酶抑制剂DL-α-单氟甲基多巴以剂量依赖方式降低小鼠纹状体对-酪胺的浓度。高香草酸也显著降低。相反，这种处理会增加间-酪胺的浓度。给予间-酪氨酸会使间-酪胺大幅增加，对-酪胺略有降低；在脱羧酶抑制剂存在的情况下，这些变化会增强。这些数据以及最近发表的其他结果表明，间-酪胺由苯丙氨酸经间-酪氨酸生成，对-酪胺由对-酪氨酸脱羧产生。这两种反应都与酪氨酸羟化酶的活性和合适底物的可用性密切相关。
