Robinson M, Gopinath C
Res Vet Sci. 1975 Jul;19(1):78-85.
A histochemical study of the effect of ischaemia on rat kidneys showed that changes were demonstrable in adenosine triphosphatase, alkaline phosphatase and succinic dehydrogenase within 2 h. Further changes occurred with increasing time. The activity of acid phosphatase was little affected up to 24 h although at this time there was marked tubular disruption. Paraffin embedded H and E sections also showed marked changes within 2 h. Enzyme histochemical and histological changes in kidneys taken at varying periods after the death of the animal showed very similar changes to those in ischaemic kidneys. Differences were mainly in the rate and extent of the changes.
一项关于缺血对大鼠肾脏影响的组织化学研究表明，2小时内三磷酸腺苷酶、碱性磷酸酶和琥珀酸脱氢酶就出现了可检测到的变化。随着时间延长，进一步的变化出现。酸性磷酸酶的活性在24小时内几乎未受影响，尽管此时肾小管有明显破坏。石蜡包埋的苏木精和伊红切片在2小时内也显示出明显变化。对动物死亡后不同时间段取出的肾脏进行酶组织化学和组织学检查，其变化与缺血肾脏的变化非常相似。差异主要在于变化的速率和程度。
