Jiang De-Jian, Tan Gui-Shan, Ye Feng, Du Yan-Hua, Xu Kang-Ping, Li Yuan-Jian
Department of Pharmacology, School of Pharmaceutic Sciences, Central South University, Changsha 410078, China.
Acta Pharmacol Sin. 2003 Feb;24(2):175-80.
To investigate the protective effect of xanthones against myocardial ischemia-reperfusion injury in rats.
Ischemia-reperfusion injury was induced by 20 min of global ischemia and 40 min of reperfusion in isolated rat hearts or 60-min coronary artery occlusion and 180-min reperfusion in vivo, respectively. Heart rate, coronary flow, left ventricular pressure (LVP), and its first derivative (+/- dp/dtmax) were recorded, and the activity of creatine kinase in coronary effluent and malondialdehyde contents in myocardial tissues were measured in vitro. The activity of serum creatine kinase and myocardium infarct size were measured in vivo.
Xanthones (90 or 300 microg/L) caused a significant improvement of cardiac function (LVP and +/- dp/dtmax) and a decrease in the release of creatine kinase in coronary effluent as well as the level of malondialdehyde in myocardial tissues. Xanthones (0.5 or 1.0 mg/kg) also markedly decreased infarct size and the release of creatine kinase in vivo.
Xanthones protect the myocardium against the damages induced by ischemia-reperfusion in rats, and the effect of xanthones may be related to the inhibition of lipid peroxidation.
研究氧杂蒽酮对大鼠心肌缺血再灌注损伤的保护作用。
分别在离体大鼠心脏中通过20分钟全心缺血和40分钟再灌注，或在体内通过60分钟冠状动脉阻塞和180分钟再灌注诱导缺血再灌注损伤。记录心率、冠状动脉血流量、左心室压力（LVP）及其一阶导数（+/- dp/dtmax），并在体外测量冠状动脉流出液中肌酸激酶的活性和心肌组织中丙二醛的含量。在体内测量血清肌酸激酶的活性和心肌梗死面积。
氧杂蒽酮（90或300微克/升）可显著改善心脏功能（LVP和+/- dp/dtmax），并减少冠状动脉流出液中肌酸激酶的释放以及心肌组织中丙二醛的水平。氧杂蒽酮（0.5或1.0毫克/千克）在体内也显著减小梗死面积并降低肌酸激酶的释放。
氧杂蒽酮可保护大鼠心肌免受缺血再灌注诱导的损伤，其作用可能与抑制脂质过氧化有关。
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