Fridén Jan, Lieber Richard L
Department of Hand Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.
Muscle Nerve. 2003 Feb;27(2):157-64. doi: 10.1002/mus.10247.
The mechanical properties of isolated single muscle fiber segments were measured in muscle cells obtained from patients undergoing surgery for correction of flexion contractures secondary to static perinatal encephalopathy (cerebral palsy). "Normal" muscle cells from patients with intact neuromuscular function were also mechanically tested. Fiber segments taken from subjects with spasticity developed passive tension at significantly shorter sarcomere lengths (1.84 +/- 0.05 microm, n = 15) than fibers taken from normal subjects (2.20 +/- 0.04 microm, n = 35). Elastic modulus of the stress-strain relationship in fibers from patients with spasticity (55.00 +/- 6.61 kPa) was almost double that measured in normal fibers (28.25 +/- 3.31 kPa). The fact that these muscle cells from patients with spasticity have a shorter resting sarcomere length and increased modulus compared with normal muscle cells suggests dramatic remodeling of intracellular or extracellular muscle structural components such as titin and collagen. Such changes in muscles of patients with spasticity may have implications for therapy.
在因静态围产期脑病（脑瘫）继发的屈曲挛缩而接受手术矫正的患者所获取的肌肉细胞中，测量了分离出的单个肌纤维节段的力学性能。还对神经肌肉功能完好的患者的“正常”肌肉细胞进行了力学测试。与取自正常受试者的纤维（2.20±0.04微米，n = 35）相比，取自痉挛患者的纤维节段在明显更短的肌节长度（1.84±0.05微米，n = 15）时就产生了被动张力。痉挛患者纤维中应力-应变关系的弹性模量（55.00±6.61千帕）几乎是正常纤维（28.25±3.31千帕）中测量值的两倍。与正常肌肉细胞相比，这些痉挛患者的肌肉细胞具有更短的静息肌节长度和更高的模量，这一事实表明细胞内或细胞外肌肉结构成分（如肌联蛋白和胶原蛋白）发生了显著重塑。痉挛患者肌肉的这种变化可能对治疗有影响。
