Agarwal R A, Rastogi R B, Singhal R L
Res Commun Chem Pathol Pharmacol. 1976 Dec;15(4):743-52.
Repeated exposure of rats to thyrotropin releasing hormone produced a dose- and time-dependent increase in spontaneous locomotor activity accompanied by an increase in brain stem tyrosine hydroxylase. Dopamine levels in cerebral cortex were increased maximally by 34% in animals receiving thyrotropin releasing hormone at a dosage of 2 mg/kg for 10 days. The concentrations of brain stem tyrosine and cerebral cortex norepinephrine remained unaltered in response to thyrotropin releasing hormone treatment. Our data suggest that administration of thyrotropin releasing hormone increases the synthesis and perhaps the turnover of brain catecholamines and that this may constitute an underlying mechanism for the anti-depressant action of this synthetic hormone.
将大鼠反复暴露于促甲状腺激素释放激素下，会导致自发运动活动呈剂量和时间依赖性增加，同时脑干酪氨酸羟化酶也会增加。接受剂量为2mg/kg的促甲状腺激素释放激素治疗10天的动物，大脑皮层中的多巴胺水平最大增加了34%。促甲状腺激素释放激素处理后，脑干酪氨酸和大脑皮层去甲肾上腺素的浓度保持不变。我们的数据表明，促甲状腺激素释放激素的给药增加了脑儿茶酚胺的合成，可能还增加了其周转，这可能构成了这种合成激素抗抑郁作用的潜在机制。
