• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过受体协作实现肿瘤细胞的靶向逆转录病毒感染

Targeted retroviral infection of tumor cells by receptor cooperation.

作者信息

Martin Francisco, Chowdhury Simon, Neil Stuart J, Chester Kerry A, Cosset Francois-Loic, Collins Mary K

机构信息

Department of Immunology and Molecular Pathology, Windeyer Institute, 46 Cleveland Street, London W1T 2AH, United Kingdom.

出版信息

J Virol. 2003 Feb;77(4):2753-6. doi: 10.1128/jvi.77.4.2753-2756.2003.

DOI:10.1128/jvi.77.4.2753-2756.2003
PMID:12552017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC141083/
Abstract

Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223, 1997). Here we apply this receptor cooperation strategy to target human tumor cells by linking single-chain antibodies recognizing tumor antigens via proline-rich spacers to the 4070A murine leukemia virus surface protein.

摘要

表达由富含脯氨酸的间隔区连接的两种不同受体结合域的逆转录病毒仅感染表达两种逆转录病毒受体的细胞（瓦尔塞西亚 - 维特曼等人，《欧洲分子生物学组织杂志》6:1214 - 1223，1997年）。在此，我们通过富含脯氨酸的间隔区将识别肿瘤抗原的单链抗体与4070A鼠白血病病毒表面蛋白相连，应用这种受体协作策略来靶向人类肿瘤细胞。

相似文献

1
Targeted retroviral infection of tumor cells by receptor cooperation.通过受体协作实现肿瘤细胞的靶向逆转录病毒感染
J Virol. 2003 Feb;77(4):2753-6. doi: 10.1128/jvi.77.4.2753-2756.2003.
2
Role of chimeric murine leukemia virus env beta-turn polyproline spacers in receptor cooperation.嵌合鼠白血病病毒envβ-转角多聚脯氨酸间隔区在受体协同作用中的作用
J Virol. 2001 Sep;75(18):8478-86. doi: 10.1128/jvi.75.18.8478-8486.2001.
3
Specifically targeted killing of carcinoembryonic antigen (CEA)-expressing cells by a retroviral vector displaying single-chain variable fragmented antibody to CEA and carrying the gene for inducible nitric oxide synthase.通过展示针对癌胚抗原（CEA）的单链可变片段抗体并携带诱导型一氧化氮合酶基因的逆转录病毒载体特异性靶向杀伤表达CEA的细胞。
Cancer Res. 2001 Jan 1;61(1):370-5.
4
Retroviral display of functional binding domains fused to the amino terminus of influenza hemagglutinin.与流感血凝素氨基末端融合的功能性结合结构域的逆转录病毒展示。
Hum Gene Ther. 1999 Jun 10;10(9):1533-44. doi: 10.1089/10430349950017860.
5
Receptor co-operation in retrovirus entry: recruitment of an auxiliary entry mechanism after retargeted binding.逆转录病毒进入过程中的受体协同作用：靶向结合后辅助进入机制的招募。
EMBO J. 1997 Mar 17;16(6):1214-23. doi: 10.1093/emboj/16.6.1214.
6
Identification of regions in the Moloney murine leukemia virus SU protein that tolerate the insertion of an integrin-binding peptide.莫洛尼鼠白血病病毒表面蛋白中可耐受整合素结合肽插入区域的鉴定
Virology. 2000 Mar 30;269(1):7-17. doi: 10.1006/viro.2000.0201.
7
Adenovirus facilitated infection of human cells with ecotropic retrovirus.腺病毒促进嗜亲性逆转录病毒对人类细胞的感染。
Gene Ther. 1998 May;5(5):621-9. doi: 10.1038/sj.gt.3300633.
8
Masking of retroviral envelope functions by oligomerizing polypeptide adaptors.通过寡聚化多肽衔接子对逆转录病毒包膜功能的掩盖
Virology. 1997 Jul 21;234(1):51-61. doi: 10.1006/viro.1997.8628.
9
Use of different but overlapping determinants in a retrovirus receptor accounts for non-reciprocal interference between xenotropic and polytropic murine leukemia viruses.逆转录病毒受体中不同但重叠的决定簇的使用解释了嗜异性和多嗜性鼠白血病病毒之间的非相互干扰。
Retrovirology. 2005 Dec 15;2:76. doi: 10.1186/1742-4690-2-76.
10
Expression of chimeric envelope proteins in helper cell lines and integration into Moloney murine leukemia virus particles.嵌合包膜蛋白在辅助细胞系中的表达及整合入莫洛尼鼠白血病病毒颗粒
Gene Ther. 1996 Apr;3(4):334-42.

引用本文的文献

1
Polysaccharide-modified scaffolds for controlled lentivirus delivery in vitro and after spinal cord injury.多糖修饰支架用于体外和脊髓损伤后慢病毒的控制递送。
J Control Release. 2013 Sep 28;170(3):421-9. doi: 10.1016/j.jconrel.2013.06.013. Epub 2013 Jun 18.
2
Library screening and receptor-directed targeting of gammaretroviral vectors.文库筛选和γ逆转录病毒载体的受体靶向。
Future Microbiol. 2013 Jan;8(1):107-21. doi: 10.2217/fmb.12.122.
3
Rapid adaptation of a recombinant vesicular stomatitis virus to a targeted cell line.重组水疱性口炎病毒对靶向细胞系的快速适应性。
J Virol. 2006 Sep;80(17):8603-12. doi: 10.1128/JVI.00142-06.

本文引用的文献

1
Envelope-targeted retrovirus vectors transduce melanoma xenografts but not spleen or liver.包膜靶向逆转录病毒载体可转导黑色素瘤异种移植物，但不能转导脾脏或肝脏。
Mol Ther. 2002 Mar;5(3):269-74. doi: 10.1006/mthe.2002.0550.
2
Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors.静脉输注靶向和非靶向慢病毒载体后基因表达的器官分布
Gene Ther. 2001 Oct;8(19):1456-63. doi: 10.1038/sj.gt.3301552.
3
Receptor binding transforms the surface subunit of the mammalian C-type retrovirus envelope protein from an inhibitor to an activator of fusion.受体结合将哺乳动物C型逆转录病毒包膜蛋白的表面亚基从融合抑制剂转变为融合激活剂。
J Virol. 2001 Oct;75(19):9096-105. doi: 10.1128/JVI.75.19.9096-9105.2001.
4
Role of chimeric murine leukemia virus env beta-turn polyproline spacers in receptor cooperation.嵌合鼠白血病病毒envβ-转角多聚脯氨酸间隔区在受体协同作用中的作用
J Virol. 2001 Sep;75(18):8478-86. doi: 10.1128/jvi.75.18.8478-8486.2001.
5
Two point mutations increase targeted transduction and stabilize vector association of a modified retroviral envelope protein.两个点突变增加了靶向转导并稳定了修饰逆转录病毒包膜蛋白的载体结合。
Mol Ther. 2001 Mar;3(3):323-8. doi: 10.1006/mthe.2001.0262.
6
Specifically targeted killing of carcinoembryonic antigen (CEA)-expressing cells by a retroviral vector displaying single-chain variable fragmented antibody to CEA and carrying the gene for inducible nitric oxide synthase.通过展示针对癌胚抗原（CEA）的单链可变片段抗体并携带诱导型一氧化氮合酶基因的逆转录病毒载体特异性靶向杀伤表达CEA的细胞。
Cancer Res. 2001 Jan 1;61(1):370-5.
7
Systemic administration of a matrix-targeted retroviral vector is efficacious for cancer gene therapy in mice.对基质靶向逆转录病毒载体进行全身给药对小鼠癌症基因治疗有效。
Hum Gene Ther. 2001 Jan 20;12(2):193-204. doi: 10.1089/104303401750061258.
8
Subcellular redistribution of Pit-2 P(i) transporter/amphotropic leukemia virus (A-MuLV) receptor in A-MuLV-infected NIH 3T3 fibroblasts: involvement in superinfection interference.Pit-2 磷酸转运体/嗜双性白血病病毒（A-MuLV）受体在 A-MuLV 感染的 NIH 3T3 成纤维细胞中的亚细胞重新分布：与超感染干扰的关系
J Virol. 2000 Mar;74(6):2847-54. doi: 10.1128/jvi.74.6.2847-2854.2000.
9
Selective transduction of protease-rich tumors by matrix-metalloproteinase-targeted retroviral vectors.基质金属蛋白酶靶向逆转录病毒载体对富含蛋白酶肿瘤的选择性转导
Gene Ther. 1999 Sep;6(9):1552-7. doi: 10.1038/sj.gt.3300982.
10
Retrovirus targeting by tropism restriction to melanoma cells.通过向黑色素瘤细胞的嗜性限制来靶向逆转录病毒。
J Virol. 1999 Aug;73(8):6923-9. doi: 10.1128/JVI.73.8.6923-6929.1999.