通过受体协作实现肿瘤细胞的靶向逆转录病毒感染
Targeted retroviral infection of tumor cells by receptor cooperation.
作者信息
Martin Francisco, Chowdhury Simon, Neil Stuart J, Chester Kerry A, Cosset Francois-Loic, Collins Mary K
机构信息
Department of Immunology and Molecular Pathology, Windeyer Institute, 46 Cleveland Street, London W1T 2AH, United Kingdom.
出版信息
J Virol. 2003 Feb;77(4):2753-6. doi: 10.1128/jvi.77.4.2753-2756.2003.
Abstract
Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223, 1997). Here we apply this receptor cooperation strategy to target human tumor cells by linking single-chain antibodies recognizing tumor antigens via proline-rich spacers to the 4070A murine leukemia virus surface protein.
摘要
表达由富含脯氨酸的间隔区连接的两种不同受体结合域的逆转录病毒仅感染表达两种逆转录病毒受体的细胞（瓦尔塞西亚 - 维特曼等人，《欧洲分子生物学组织杂志》6:1214 - 1223，1997年）。在此，我们通过富含脯氨酸的间隔区将识别肿瘤抗原的单链抗体与4070A鼠白血病病毒表面蛋白相连，应用这种受体协作策略来靶向人类肿瘤细胞。
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