Cabral Teresa, Jolly Ann M, Wylie John L
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
J Infect Dis. 2003 Jan 15;187(2):279-86. doi: 10.1086/346048. Epub 2003 Jan 6.
Sexual and social network analysis have been proposed as novel sexually transmitted disease control and research tools. Here, the concordance between chlamydia genotype data and a large sexual network constructed from routinely collected contact tracing data was examined. A sexual network was constructed for Manitoba, Canada, from province-wide contact tracing data. Positive chlamydia specimens from the same time period were collected and genotyped by omp1 DNA sequencing. A high degree of concordance was found between transmission events, on the basis of molecular data, and proposed transmission events, on the basis of sexual network data. Discordant results appeared to occur when a portion of the network contained potential core group members or in areas where contact tracing is difficult to carry out. The agreement between the molecular and epidemiologic data suggests that the use of routine contact tracing data is a valid approach for the construction of sexual networks.
性网络和社交网络分析已被提议作为新型性传播疾病控制和研究工具。在此，研究了衣原体基因型数据与根据常规收集的接触者追踪数据构建的大型性网络之间的一致性。利用加拿大曼尼托巴省全省范围的接触者追踪数据构建了一个性网络。收集了同一时期衣原体检测呈阳性的标本，并通过omp1 DNA测序进行基因分型。基于分子数据的传播事件与基于性网络数据的推测传播事件之间发现了高度一致性。当网络的一部分包含潜在的核心组成员或在接触者追踪难以开展的地区时，似乎会出现不一致的结果。分子数据和流行病学数据之间的一致性表明，使用常规接触者追踪数据是构建性网络的有效方法。
