[The resolution of racemic sec-phenethyl alcohol on cellulose tribenzoate-based CSP: influence of different alcohols in the mobile phase].

Several primary and secondary alcohols (ethanol, 1-propanol, 2-propanol, 1-butanol) were used as the mobile phase components separately, to investigate their effects on the capacity factor and stereoselectivity of sec-phenethyl alcohol enantiomers on cellulose tribenzoate-based CSP. The chiral recognition mechanism for the enantiomeric aromatic alcohols studied may involve: (1) the aromatic portion of the solute may insert into a chiral cavity of the CSP through a hydrogen bonding interaction between the solute's alcoholic hydrogen and the ester carbonyl group on the CSP; (2) the mobile phase modifiers (various alcohols) compete with the solutes for chiral, as well as achiral, binding sites on the CSP; (3) the structure of the modifier has some effect on stereoselectivity through an alteration of the steric environment of the chiral cavity.